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The study analyzes the real state of the social and economic spheres of Ukraine as a fundamental component of national security and defense. On this basis, possible security threats to Ukraine over the time horizon until 2030 and important characteristics of the future defense-industrial complex of Ukraine are analyzed. Using the Delphi method, the necessary main clusters of the future defense industry of the country were studied, the priority of the contribution of each defense cluster to the overall growth of Ukraine’s security was studied and important characteristics of the renewed defense-industrial complex were analyzed with which Ukraine would be able, by asymmetric means, to deter external aggression on the time horizon until 2030. A complex of works on Foresight of a set of possible scenarios of future events in Ukraine was performed, which can be used as a basis for developing a strategy to protect the country and its further peaceful, sustainable development.